LRRK2 at the pre?synaptic site: A 16?years perspective

Parkinson's disease is a common neurodegenerative disorder and clinically characterized by bradykinesia, rigidity, resting tremor. Missense mutations in the leucine-rich repeat protein kinase-2 gene (LRRK2) are recognized cause of inherited disease. The physiological pathological impact LRRK2 still obscure, but accumulating evidence indicates that orchestrates diverse aspects membrane trafficking, such as fusion vesicle formation transport along actin tubulin tracks. In present review, we focus on special relation between synaptic vesicles. binds phosphorylates key actors within cycle. Accordingly, alterations dopamine glutamate transmission have been described upon manipulations. However, different modeling strategies phenotypes observed require critical approach to decipher outcome at pre-synaptic site.